Neurocutaneous Disorders

What Are Neurocutaneous Disorders?

Neurocutaneous disorders are conditions that cause tumors to grow inside the brain, spinal cord, organs, skin and bones. There are several types of neurocutaneous disorders, which may result from an inherited gene mutation but could also result from a spontaneous gene mutation as an embryo

Who’s on Our Team?

The Division of Neurology and the Division of Medical Genetics jointly run the Comprehensive Neurofibromatosis Clinic. Our expert team includes specialists from multiple disciplines, including:

  • Neurologists, neurosurgeons and neuro-oncologists
  • General surgeons, orthopaedic surgeons and plastic surgeons
  • Oncologists, cardiologists and endocrinologists
  • Ear, nose and throat (ENT) doctors
  • Ophthalmologists and audiologists
  • Genetic counselors

Neurocutaneous disorders require specialized, lifelong management. At Children’s Hospital Los Angeles, your child will receive the most advanced, personalized treatment from our highly experienced team.

Conditions We Treat

Our team has the expertise and experience to treat a variety of complex neurocutaneous disorders. These include:

  • Neurofibromatosis type 1 (NF1): NF1 is the most common neurocutaneous syndrome. People with this condition often develop non-cancerous tumors on nerves in the brain, skin and other areas of the body. A classic sign of this disorder is when a child has several coffee-colored birth marks. These are non-cancerous skin tumors called neurofibromas.
  • Neurofibromatosis type 2 (NF2): This disorder can cause tumors to grow in the nerves leading to the ears, resulting in hearing and balance problems. People with this disorder also have an increased risk of developing tumors elsewhere in the nervous system.
  • Schwannomatosis: This rare condition causes non-cancerous growths in the peripheral nerves, which are the nerves outside the spinal cord and brain. These growths can cause pain, numbness, weakness and headaches.
  • Tuberous sclerosis (TS): This disorder causes non-cancerous growths to form on organs—including the brain, eyes, kidney, heart, lungs and skin. It can cause developmental delays, seizures and behavioral problems.